######################################################################### # Joseph F. Contrera, Abigail C. Jacobs, and Joseph J. DeGeorge: # # Carcinogenicity Testing and the Evaluation of Regulatory Requirements # # for Pharmaceuticals, Regulatory Toxicology and Pharmacology 25, # # 130-145 (1997) # # # # Pharmaceuticals with Rat and Mouse Carcinogenicity Studies # ######################################################################### ID Name MR FR MM FM 1 Acetaminophen - - + + 2 Acebutolol - - - - 3 Acetohexamide - - - - 4 149 + + + + 5 Acrivastine - - - - 6 Acyclovir - - - - 7 298 + - - - 8 Allopurinol - - - - 9 196 + - + - 10 308 - - - - 11 Amiloride - - - - 12 Amino-5-nitrothiazole + - - - 13 439 - - - - 14 Amlodipine - - - - 15 Amphetamine - - - - 16 Ampicillin - - - - 17 Amrinone - - - - 18 Astemizole - - - - 19 Atenolol + + - - 20 Auranofin + + - - 21 140 - - - - 22 219 - - - - 23 202 + - - - 24 Benazepril - - - - 25 Bepridil + + - - 26 Betaxolol - - - - 27 236 - - - - 28 Bisoprolol - - - - 29 Bitolterol - - - - 30 Brotizolam + + - - 31 Budesonide + - - - 32 Bunolol + - - + 33 Bupropion - - - - 34 Buspirone - - - - 35 336 + - - - 36 Captopril - - - - 37 Carbromal - - - - 38 Carteolol - - - - 39 176 - - - - 40 Cetirizine - - - - 41 Chlordiazepoxide - - + + 42 Chlorpheniramine - - - - 43 Chlorpromazine + - - - 44 Chlorpropamide - - - - 45 189 + + - - 46 Ciprofloxacin - - - - 47 Cisapride - - - - 48 Clemastine - - - - 49 132 + - + - 50 331 - - - - 51 Clozapine - - - - 52 Codeine - - - - 53 Coumarin + - + + 54 Cyclobenzaprine - - - - 55 Cyclosporine - - + + 56 Dacarbazine + + + + 57 Dantrolene - - - - 58 Dapsone + + - - 59 Desogen + + + + 60 Dexfenfluramine - - - - 61 Diazepam - - + + 62 Diclofenac - - - - 63 Didanosine - - - - 64 Diflunisal - - - - 65 Diltiazem - + - - 66 Diphenhydramine - - - - 67 Dipyridamole - - - - 68 239 + + + + 69 301 - - - - 70 Doxazosin - - - - 71 Doxylamine + - + + 72 Dronabinol - - - - 73 Enalapril - - - - 74 Ephedrine - - - - 75 Erythromycin - - - - 76 Estazolam - - - - 77 Estradiol mustard - - + + 78 Etchlorvynol - - - - 79 Ethionamide - - - - 80 Etodolac - - - - 81 Etretinate - - + - 82 Eugenol - - - - 83 Famciclovir - + - - 84 Famotidine - - - - 85 Felbamate + - - - 86 12 - - - - 87 201 + + + + 88 Finasteride + - + - 89 Flecainide - - - - 90 184 + - - - 91 Fluconazole + - - - 92 Flunisolide - + + + 93 229 + - - - 94 Fluoxetine - - - - 95 Flurazepam - - - - 96 Flurbiprofen - - - - 97 Fluvastatin + - - - 98 Foscarnet - - - - 99 Fosinopril + + - - 100 Furazolidone - + + + 101 Furosemide - - - + 102 Gabapentin + - - - 103 Gemfibrozil + - - - 104 29 + + + + 105 Glipizide - - - - 106 Glyburide - - - - 107 Granisetron + + + - 108 Guanadrel + - - - 109 Guanfacine - - - - 110 127 - - - - 111 Hexylresorcinol, 4- - - - - 112 Hydralazine + + + + 113 Hydrochlorothiazide - - - - 114 Hydroxyquinoline, 8- - - - - 115 Indapamide - - - - 116 206 - - - - 117 Indomethacine - - - - 118 Iodinated glycerol + - - + 119 Iodoform - - - - 120 Ipratropium - - - - 121 Isosorbide - - - - 122 Isradipine + - - - 123 Itraconazole + - - - 124 136 - - - - 125 Ketoconazole - - - - 126 Ketoprofen - - - - 127 Ketorolac - - - - 128 Labetalol - - - + 129 Lamotrigine - - - - 130 Lansoprazole + + + + 131 393 - + - - 132 Levamisole - - - - 133 Levomethadone - - - - 134 Loratidine - - + - 135 Lorazepam - - - - 136 126 - - - - 137 322 - + - - 138 Lovastatin + - + + 139 Mannitol - - - - 140 Mebendazole - - - - 141 312 - - - + 142 Mefloquine - - - - 143 Menthol - - - - 144 Metaproterenol - - + + 145 274 + + - - 146 alpha-Methyldopa - - - - 147 Methylphenidate - - + + 148 Metolazone - - - - 149 Metoprolol - - - - 150 Metronidazole + + + + 151 Mexiletine - - - - 152 Midazolam + - - + 153 Milrinone - - - - 154 Minocycline + + - - 155 Misoprostol - - - - 156 223 - - - - 157 Moricizine + + - + 158 Mycophenolate - - - - 159 Nabumetone - - - - 160 Nadolol - - - - 161 Nafenopin + - + + 162 Nalidixic acid + + - - 163 Nedocromil - - - - 164 Nefazodone - - - - 165 Netilmicin - - - - 166 Nicardipine + + - - 167 Nimodipine + - - - 168 Nisoldipine - - - - 169 Nithiazide - + + - 170 Nitroacetophenetide - - + - 171 Nitrofurantoin + + + + 172 Nitrofurazone - + - + 173 Nizatidine - - - + 174 Omeprazole + + - - 175 Ondansetron - - - - 176 Olsalazine - - - - 177 Oxaprozin - - + - 178 Oxazepam + - + + 179 313 - - - - 180 Oxytetracycline - - - - 181 315 + + - - 182 Pamidronic acid + - - - 183 304 + + - + 184 Paroxetine - - - - 185 Penbutolol - - - - 186 111 + + - + 187 Penicillin - - - - 188 Pentaerythritol - - - - 189 Pentoxifylline - - - - 190 Pergolide - + - + 191 Perindopril - + - + 192 Permethrin - - + + 193 Phenazopyridine + + - + 194 Phenformin - - - - 195 Phenole - - - - 196 Phenolphthalein + - + + 197 Phenylbutazone - + + - 198 Phenylephrine - - - - 199 Phenytoin - - - + 200 Pimozide - - - + 201 Pindolol - - - - 202 Pirbuterol - - - - 203 183 - - - - 204 Piroxicam - - - - 205 Polysorbate 80 - - - - 206 318 - - - - 207 Pravastatin + - - - 208 Prazepam - - - - 209 Probenecid - - - + 210 Procarbazine + + + + 211 327 - + - - 212 Promethazine - - - - 213 Propafenone - - - - 214 Propranolol - - - - 215 Pyrazinamide - - - + 216 Pyrilamine - - - - 217 Pyrimethamine - - - - 218 Quinapril - + - - 219 Ramipril - - - + 220 Ranitidine - - - - 221 187 - - - - 222 Reserpine + + + + 223 Resorcinol - - - - 224 Ribavirin + + - - 225 Rifabutin - - - - 226 Rifampin - - - + 227 Ripazepam - - + - 228 Risperidone + + - + 229 208 - - - - 230 182 + + + + 231 Scopolamine - - - - 232 Selenium sulfide + + - + 233 Sertraline + + + + 234 Simvastatin + + + + 235 Sodium Fluoride - - + - 236 11 + + + + 237 Sotalol - - - - 238 267 - - - - 239 Sucralfate - - - - 240 Sulfadiazine - - - - 241 Sulfamethazine + + + + 242 Sulfasalazine + - + - 243 Sulfisoxazole - - - - 244 138 + + - + 245 Sumatriptan - - - - 246 Tamoxifen + + + + 247 Temazepam - - - - 248 Terazosin + - - - 249 Terbinafine + - + + 250 Terbutaline - + - - 251 Terfenadine - - - - 252 124 - - - - 253 Tetracycline - - - - 254 Theophylline - - - - 255 Thiabendazole + - - - 256 212 - - - - 257 Ticlopidine - - - - 258 Timolol + + - + 259 Tocainide - - - - 260 320 + + - + 261 Tolazamide - - - - 262 Tolbutamide - - - - 263 Tolmetin - - - - 264 329 - - + + 265 235 - - + + 266 Torsemide + + - - 267 Tramadol - - + - 268 440 - - - - 269 Triamterene - - + + 270 Triprolidine - - - - 271 Tryptophan - - - - 272 Ursodeoxycholic acid + + - - 273 Valaciclovir - - - - 274 Valproic acid + + + - 275 Venlafaxine - - - - 276 Verapamil - - - - 277 234 + + + + 278 338 - - - - 279 Zidovudine - + - + 280 148 + + - + 281 Zolpidem + - - - 282 133 + + + -