NTP RESULTS REPORT RESULTS, STATUS AND PUBLICATION INFORMATION ON ALL NTP CHEMICALS PRODUCED FROM NTP CHEMTRACK SYSTEM FOR ADDITIONAL INFORMATION ON CHEMICALS CONTAINED IN THIS REPORT, CONTACT: CENTRAL DATA MANAGEMENT 919-541-3419 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 1 Some documents listed in this report have been registered with the National Technical Information Service (NTIS) and appear with NTIS accession numbers. These documents may be ordered from NTIS by calling (703) 605-6000 or 1-800-553-6847 (rush orders only) or writing National Technical Information Service, Department of Commerce, 5285 Port Royal Road, Springfield, VA 22161. The abstracts for all published long-term NTP technical reports are available in Volume 101, Supplement 1 of ENVIRONMENTAL HEALTH PERSPECTIVES (EHP) (1993) and electronically on the National Toxicology Program Worldwide web (WWW) site. To view this information requires access to the Internet and a software client such as Netscape or Internet Explorer. The Worldwide Web server is located at NIEHS; the address (URL) to access the NTP Worldwide Web Homepage is http://ntp-server.niehs.nih.gov/. Printed copies of Technical Reports on NTP toxicology and carcinogenesis studies and short-term toxicity studies are available through the Environmental Health Information Service (EHIS). This subscription service was established in FY 1997 to generate and distribute relevant environmental health information. In addition to distributing a number of hardcopy documents, these documents will be made available electronically over the World Wide Web. The address (URL) to access EHIS is http://ehis.niehs.nih.gov/. If you have further questions about electronic access or to request a copy of EHP, VOL. 101, contact CENTRAL DATA MANAGEMENT, MAIL DROP E1-02, NIEHS, P. O. BOX 12233, RESEARCH TRIANGLE PARK, NC 27709 (TELEPHONE: 919-541-3419; FAX: 919-558-7056 or 919-541-3687; E-MAIL: CDM@NIEHS.NIH.GOV). CARCINOGENICITY/TOXICOLOGY STUDIES (COLUMN 3): FOR ADDITIONAL INFORMATION, CONTACT THE CENTRAL DATA MANAGEMENT GROUP AT 919-541-3419. MR = MALE RATS; FR = FEMALE RATS; MM = MALE MICE; FM = FEMALE MICE 14-SD (ACUTE), 14-RD (REPEAT DOSE), 90-DAY (SUBCHRONIC), AND CHRONIC ROUTE CODES FEED - DOSED-FEED GAV - GAVAGE IM - INTRAMUSCULAR INJECTION INHAL - INHALATION IP/IJ - INTRAPERITONEAL INJECTION IT - INTRATRACHEAL IVAG - INTRAVAGINAL MICRO - MICROENCAPSULATION IN FEED SC&GV - SUBCUTANEOUS INJ. + GAVAGE SC/IJ - SUBCUTANEOUS INJECTION SP - TOPICAL WATER - DOSED-WATER For each separate carcinogenicity experiment (male rats, female rats, male mice, female mice), one of the following codes is selected to describe the findings. The categories refer to the strength of the experimental evidence and not to either potency or mechanism. CE Clear Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a dose-related (i) increase of malignant neoplasms, (ii) increase of a combination of malignant and benign neoplasms, or (iii) marked increase of benign neoplasms if there is an indication from this or other studies of the ability of such tumors to progress to malignancy. SE Some Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a chemically-related increased incidence of neoplasms (malignant, benign, or combined) in which the strength of the response is less than that required for clear evidence. EE Equivocal Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a marginal increase of neoplasms that may be chemically related. NE No Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing no chemically-related increases in malignant or benign neoplasms. IS Inadequate Study of Carcinogenic Activity is demonstrated by studies that because of major qualitative or quantitative limitations cannot be interpreted as valid for showing either the presence or absence of carcinogenic activity. Earlier designations include: P Positive E Equivocal N Negative RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 2 ABBREVIATIONS USED IN THIS REPORT AND INFORMATION CONTACTS: CHEMICAL DISPOSITION/SPECIAL STUDIES (COLUMN 4): FOR ADDITIONAL INFORMATION, CONTACT THE CENTRAL DATA MANAGEMENT GROUP AT 919-541-3419. CHEMICAL DISPOSITION/SPECIAL STUDIES TESTTYPES AND CODES: BIOSAMPLE METHOD DEVELOPMENT (BSMD) METABOLISM CHEMICAL DISPOSITION (CHEM DISP) MECHANISMS CELL PROLIFERATION (CELL PROLIF) ROUTINE BIOSAMPLE ANALYSIS (RBSA) HUMAN METABOLISM (HUMAN METAB) TOXICOKINETIC STUDY (TKS) GENETIC TOXICOLOGY (COLUMN 5): FOR ADDITIONAL INFORMATION, CONTACT THE CENTRAL DATA MANAGEMENT GROUP AT 919-541-3419. GENETIC TOXICOLOGY TESTTYPE CODES: SA, SA-N - SALMONELLA IN VIVO CYTOGENETICS: SR - SALMONELLA REDUCTION MN - MICRONUCLEUS ML, ML-N - MOUSE LYMPHOMA CA - CHROMOSOME ABERRATIONS DL - DROSOPHILA (SLRL/RT) SC - SISTER CHROMATID EXCHANGES CY - IN VITRO CYTOGENETICS (CA/SCE) SH - SHE CELL TRANSFORMATION RESULTS CODES + - POSITIVE RESPONSE -/- - (DL) SEX-LINKED RECESSIVE LETHAL/RECIPROCAL TRANSLOCATION +W - WEAKLY POSITIVE -/- - (CY) CHROMOSOME ABERRATIONS/SCE'S - - NEGATIVE RESPONSE -/- - (MN) MALE/FEMALE ? - INCONCLUSIVE ORGAN SYSTEMS TOXICITY (COLUMN 6): FOR ADDITIONAL INFORMATION, CONTACT THE CENTRAL DATA MANAGEMENT GROUP AT 919-541-3419. SYSTEMS TOXICITY TESTTYPE CODES: * BSLT - BIOCHEMICAL SPECIFIC LOCUS TEST DLA - DOMINANT LETHAL * DLF/DLM - DOMINANT LETHAL FEMALE/MALE * HTT - HERITABLE TRANSLOCATION TEST IMM - IMMUNOTOXICITY, SENSITIZER, ASTHMOGENIC JPA - JUVENILE PESTICIDE ASSESSMENT * MSLT - MORPHOLOGICAL SPECIFIC LOCUS TEST NTA - NEUROTOXICOLOGY ASSESSMENT * PZE - PREIMPLANTATION ZYGOTE EFFECTS RACB - CONTINUOUS BREEDING RDGT - REPRO/DEV GEN TOX (28-DAY) SPINH - SPERMIATION INHIBITION STIV - SHORT-TERM IN VIVO REPRO. TOX. TER - CONVENTIONAL TERATOLOGY TRC - TOTAL REPRODUCTIVE CAPACITY TRP - TERATOLOGY PILOT STUDIES Immunotox: For the purposes of these studies, positives (+) were established on the basis that the test material produced a significant dose-response effect, excluding body weight, in any one or more tests or significantly (P<0.05 vs. control values) altered two or more tests at the highest dose level tested. Sensitizer: Positives (+) indicate contact sensitizer positive in guinea pigs and/or mouse. Publication numbers identified as "PUB #" in this column refer to the publication list on the following page. * Testtype codes for Germ Cell Publication/Studies PUBLICATIONS RELATING TO GERM-CELL STUDIES 1. Shelby, M.D., Cain, K.T., Hughes, L.A., Braden, P.W., and Generoso, W.M. Dominant lethal effects of acrylamide in male mice. Mutation Res. 173:35-40 (1986). 2. Shelby, M.D., Cain, K.T., Cornett, C.V., and Generoso, W.M. (1987) Acrylamide: Induction of heritable translocations in male mice. Environ. Mutagen. 9:363-368 (1987). 3. Russell, L.B., Hunsicker, P., Cacheiro, N.L.A., and Generoso, W.M. Induction of specific-locus mutations in the germ cells of the mouse by acrylamide monomer. Mutation Res. 262:101-107 (1991). 4. Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Bishop, J.B., and Generoso, W.M. Female-specific dominant lethal effects in mice. Mutation Res. 230:205-217 (1990). 5. Sudman, P.D. and Generoso, W.M. Female-specific mutagenic response of mice to hycanthone. Mutation Res. 246: 31-43 (1991). 6. Russell, L.B., Russell, W.L., Rinchik, E.M., and Hunsicker, P.R. Factors affecting the nature of induced mutations. In: Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis (J. Allen, B. Bridges, M. Lyon, M. Moses and L.B. Russell, Eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1990, pp. 271-289. 7. Gutierrez-Espeleta, G.A., Hughes, L.A., Piegorsch, W., Shelby, M.D., and Generoso, W.M. Acrylamide: Dermal Exposure Produces Genetic Damage in Male Mouse Germ Cells. Fund. Appl. Tox. 18: 189-192 (1992). 8. Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987). 9. Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P.W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193. 10. Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L.B. A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stem cells. Mutation Res. 226:61-64 (1989). 11. Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992). 12. Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984). 13. Generoso, W.M., Cain, K.T., and Hughes, L.A. Tests for dominant Lethal effects of 1,2-dibromo-2-chloropropane in male and female mice. Mutation Res. 156:103-108 (1985). 14. Shelby, M.D., Gutierrez-Espeleta, G.A., Generoso, W.M., and McFee, A.F. Mouse dominant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone. Mutation Res. 250:431-437 (1991). 15. Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282: 127-133 (1992). 16. Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental response of zygotes exposed to similar mutagens. Mutation Res. 250:439-446 (1991). 17. Russell, L.B. and Hunsicker, P.R. Study of the base analog 6-mercaptopurine in the mouse specific-locus test. Mutation Res. 176:47-52 (1987). 18. Rutledge, J.C., Cain, K.T., Kyle, J., Cornett, C.V., Cacheiro, N.L.A., Witt, K., Shelby, M.D. and Generoso, W.M. Increased incidence of developmental anomalies among descendants of carriers of methylenebisacrylamide-induced balanced reciprocal translocations. Mutation Res. 229:161-172 (1990). 19. Generoso, W.M, Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Mitchell, T.J., and Bishop, J.B. Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. Mutation Res. 210:313-322 (1989). 20. Generoso, W.M., Cain, K.T., Cornett, C.V., and Shelby, M.D. Test for induction of dominant-lethal mutations and heritable translocations with tetrahydrocannabinol in male mice. Mutation Res. 143:51-53 (1985). 21. Russell, L.B., Hunsicker, P.R., Oakberg, E.F., Cummings, C.C. and Schmoyer, R.L. Test for urethane induction of germ-cell mutations and germ cell killing in the mouse. Mutation Res. 188:335-342 (1987). 22. Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990). 23. Russell, L.B., Hunsicker, P.R., Cacheiro, N.L.A., Bangham, J.W., Russell, W.L., and Shelby, M.D. Chlorambucil effectively induces deletion mutations in mouse germ cells, Proc. Natl. Acad. Sci. (USA), 86:3704-3708 (1989). 24. Russell, L.B., Hunsicker, R.R., and Cacheiro, N.L.A. Mouse specific locus test for the induction of heritable gene mutations by dibromochloropropane (DBCP). Mutation Res. 170:161-166 (1986). 25. Lewis, S.E., Barnett, L.B., Felton, C., Johnson, F.M., Skow, L.C., Cacheiro, N., and Shelby, M.D. Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Environ. Mutagen. 8:867-872 (1986). 26. Russell, L.B., Hunsicker, P.R., and Shelby, M.D. Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids. Mutation Res. 282: 151-158 (1992). 27. Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355. 28. Russell, L.B., Cummings, R.B., and Hunsicker, P.R. Specific-Locus mutation rates in the mouse following inhalation of ethylene oxide and application of the results estimation of human genetic risk. Mutation Res. 129:381-388 (1984). 29. Russell, W.L. and Hunsicker, P.R. Extreme sensitivity of one particular germ cell stage in male mice to induction of specific-locus mutations by methylnitrosourea. Environ. Mutagen. 5:498 (1983) 30. Lewis, S., Barnett, L., and Shelby, M. ENU mutagenesis in the mouse electrophoretic specific-locus test 2. Mutational studies of mature oocytes. Mutation Res. 296: 129-134 (1992). 31. Lewis, S., and Johnson, F. (1982) Dominant and recessive effects of electrophoretically detected specific locus mutation. In: Workshop on Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk, F. de Serres, and W. Sheridan, (Eds), (Plenum Publishing Corp., New York), pp. 267-278. 32. Lewis, S., and Johnson, F. (1986) The nature of spontaneous and induced electrophoretically detected mutations in the mouse. In: Genetic Toxicology of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis, C. Ramel, B. Lambert, and J. Magnusson, (Eds.), (A.R. Liss, Inc., New York, NY), pp. 359-365. 33. Lewis, S., Barnett, L, and Popp, R. (1990) Mosaic Mutants Induced by Ethylnitrosourea in Late Germ Cells of Mice. In: Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis, J. Allen, B. Bridges, M. Lyon, M. Moses, and L. Russell, (Eds.), (CSH Laboratory Press, Cold Spring Harbor), ppp. 237-245. 34. Lewis, L., Barnett, L., Sadler, B., and Shelby, M. (1991) ENU mutagenesis in the mouse electrophoretic specific locus test 1. Dose-response relationship of electrophoretically-detected mutations arising from mouse spermatogonia treated with ENU. Mutation Res. 249: 311-316. 35. Rutledge, J.C., Generoso, W.M., Shourbaji, A., Cain, K.T., Gans, M., and Oliva, J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutation Research 296: 167-177 (1992). 36. Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Downing, D.J. Mutagen-induced fetal anomalies and death following treatment of females within hours after mating. Mutation Res. 199: 175-181 (1988). 37. Shelby, MD, Russell, LB, Generoso, W. (1995) AZT, rodent somatic and germ cell mutagenicity and reproductive toxicity tests. Environ. Mol. Mutagen. 25 (Suppl.25): 48. 38. Generoso, WM, Witt, KL, Cain, KT, Hughes, L, Cacheiro, NLA, Lockhart, A-MC, Shelby, MD. (1995) Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat. Res. 345: 167-180. 39. Russell, LB, Hunsicker, PR, and Shelby, MD. Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice. Mutation Res. 358: 25-35 (1996). 40. Generoso, WM, Sega, GA, Lockhart, AM, Hughes, LA, Cain, KT, Cacheiro, NLA, and Shelby, MD. Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide. Mutation Res. 371: 175-183 (1996). 41. Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997). 42. Rutledge, JC, Shourbaji, AG, Hughes, LA, Polifka, JE, Cruz, UP, Bishop, JB, and Generoso, WM. Limb and lower-body duplications induced by retinoic acid in mice. Proc. Natl. Acad. Sci. USA 91:5436-5440 (1994). DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 7 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3TC (AIDS INITIATIVE) (AIDS |134678-17-4 | | | | | | INITIATIVE) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACENAPHTHENE |83-32-9 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACESULFAME POTASSIUM |55589-62-3 | |TKS (GAV, IV), ON | | | | | | |TEST | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETALDEHYDE |75-07-0 | | |SA, -,-,- | | | | | | |DL, +/- | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETAMIDE (SEE ALSO N-(4- |60-35-5 | | |SA, - | | | FLUORENYL)ACETAMIDE 28322-02-| | | |DL, - | | | 3) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-ACETAMIDOBENZOIC ACID |556-08-1 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETAMINOPHEN (4- |103-90-2 |TR-394, FEED, MR=NE | |SA, - |RACB, MALE:-;FEMALE:+, | | HYDROXYACETANILIDE) | | FR=EE, MM=NE, FM=NE | |CY, +/+ |NTIS # PB85-204667 | | | | NTIS # PB93-227478 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETANILIDE |103-84-4 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETIC ACID |64-19-7 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETIC ANHYDRIDE |108-24-7 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETIN |26446-35-5 | | |SA, + | | | | | | |DL, +/+ | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETOACETANILIDE |102-01-2 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETOCHLOR |34256-82-1 | | | |TRC, COMPLETED | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETOHEXAMIDE |968-81-0 |TR-050, FEED, MR=N | |SA, - | | | | | FR=N, MM=N, FM=N | |SA-N, - | | | | | NTIS # PB284673 | |ML, - | | | | | | |CY, -/NT | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETOIN |513-86-0 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETONE |67-64-1 |TOX-03, WATER, RPT COMP| |SA, - |TER, MAT:+;FET:+, NTIS | | | | NTIS # PB91-185975 | |CY, -/- |# DE89005671; TER, MAT:| | | | | |MN, -/- |+;FET:+, NTIS # | | | | | | |DE89005671 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 8 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETONITRILE |75-05-8 |INHAL, COMPLETED PRECHR|MECHANISMS, |SA, -,- |TER, MAT:?;FET:-, NTIS | | | |TR-447, INHAL, MR=EE |PUBLICATION |CY, ?/+W |# DE94008272 | | | | FR=NE, MM=NE, FM=NE | |MN, +/- | | | | | NTIS # PB96-214937 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETALDEHYDE OXIME |107-29-9 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-ACETYLAMINOFLUORENE |53-96-3 | | |SA-N, + |DLF, -, PUB # 9; DLF, -| | | | | |ML, +,+ |, PUB # 9 | | | | | |CY, +/+ | | | | | | |CA, +*,+,+,- | | | | | | |SC, +,+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 4-ACETYLAMINOFLUORENE (SEE |28322-02-3 | | |SA-N, + |DLF, -, PUB # 9; DLF, -| | ALSO ACETAMIDE 60-35-5) | | | |ML, -,+,+,+ |, PUB # 9 | | | | | |CY, -/+ | | | | | | |CA, - | | | | | | |SC, ? | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | N-ACETYL-M-AMINOPHENOL |621-42-1 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETYLCHLORIDE |75-36-5 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 1-ACETYL-2-PHENYL HYDRAZIDE |114-83-0 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 1-ACETYL-2-PICOLINOYL |17433-31-7 | | |SA, - | | | HYDRAZINE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-ACETYLPYRIDINE |1122-62-9 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 4-ACETYL PYRIDINE |1122-54-9 | | |SA, - | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETYLSALICYLIC ACID |50-78-2 | | |SA, -,- | | | | | | |SA-N, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | N-ACETYL-M-TOLUIDINE (SEE |537-92-8 | | |SA, - | | | ALSO N-ACETYL-P-TOLUIDINE | | | | | | | (103-89-9) & ACETYL-O- | | | | | | | TOLUIDINE (120-66-1)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACETYL-O-TOLUIDINE (SEE ALSO:|120-66-1 | | |SA, +W | | | N-ACETYL-M-TOLUIDINE (537-92-| | | | | | | 8) & N-ACETYL-P-TOLUIDINE | | | | | | | (103-89-9)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | N-ACETYL-P-TOLUIDINE (SEE |103-89-9 | | |SA, +W | | | ALSO N-ACETYL-M-TOLUIDINE | | | | | | | (537-92-8) & ACETYL-O- | | | | | | | TOLUIDINE (120-66-1)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 9 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACROLEIN |107-02-8 |TOX-48, GAV, SUBCH TOX | |SA, +W,- | | | | | | |DL, -,- | | | | | | |CY, -/+W | | | | | | |MN, -/- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACRONYCINE |7008-42-6 |TR-049, IP/IJ, MR=P | | | | | | | FR=P, MM=IS, FM=IS | | | | | | | NTIS # PB283347 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACRYLAMIDE |79-06-1 | |CHEM DISP (GAV), |SA, -,+W |DLM, +, PUB # 1,7; HTT,| | | | |REPORTS & |DL, - |+, PUB # 2; MSLT, +, | | | | |PUBLICATION; OTHER, |CY, +/+ |PUB # 3; NTA, | | | | |PUBLICATION; OTHER |CA, +* |COMPLETED; PZE, +, PUB | | | | |(IP/IJ), PUBLICATION |SC, + |# 35; RACB, MALE: | | | | | | |+;FEMALE:-, NTIS # | | | | | | |PB93-158285; TER, MAT:-| | | | | | |;FET:-, NTIS # PB89- | | | | | | |164669; TER, MAT:+;FET:| | | | | | |+, NTIS # PB89-140008; | | | | | | |TRC, -, PUB # 41 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACRYLIC ACID |79-10-7 | | |SA, -,- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACRYLONITRILE |107-13-1 |TR-506, GAV, HISTO |CHEM DISP, |SA, + | | | | | |PUBLICATION; OTHER, |ML, + | | | | | |PUBLICATION |DL, -/- | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ACTINOMYCIN D |50-76-0 |TR-00A, IP/IJ, RPT COMP| |MN, +/+ |TRC, COMPLETED | | | | NTIS # JOURNAL ART | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ADIPAMIDE |628-94-4 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ADIPIC ACID |124-04-9 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ADIPONITRILE |111-69-3 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ADRIAMYCIN |23214-92-8 | | | |DLF, +, PUB # 10; DLF, | | | | | | |+, PUB # 10; DLM, -, | | | | | | |PUB # 10 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ADRIAMYCIN, HYDROCHLORIDE |25316-40-9 | | |MN, + |TRC, +, PUB # 41 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AF-2 |3688-53-7 | | |SA, +,+,+,+,+,+| | | | | | |SA, +,+,+,+ | | | | | | |DL, +/- | | | | | | |CY, +/+,+W/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-2 |EMTDP-02 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 10 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN-B1 (SEE ALSO |1162-65-8 | |OTHER, PUBLICATION |SA, + | | | AFLATOXIN-B2 (CAS 7220-81-7) | | | | | | | & AFLATOXINS (CAS 1402-68-2))| | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (AA34-3-|EMTDP-11 | | |SA, + | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (N1D- |EMTDP-12 | | |SA, +,+ | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (P-1-AC-|EMTDP-13 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (P-1-ME-|EMTDP-14 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D3- |EMTDP-16 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D4- |EMTDP-17 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D5- |EMTDP-18 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D6- |EMTDP-19 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D7- |EMTDP-20 | | |SA, ? | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D- |EMTDP-15 | | |SA, ? | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1D8- |EMTDP-21 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1E- |EMTDP-22 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1J2- |EMTDP-23 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1K1- |EMTDP-24 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1K2- |EMTDP-27 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 11 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1L1- |EMTDP-25 | | |SA, - | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN DERIVATIVE (T1M1- |EMTDP-26 | | |SA, + | | | 82107) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-1 |EMTDP-01 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-4 |EMTDP-03 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-5 |EMTDP-04 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-10 |EMTDP-09 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-6 |EMTDP-05 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-7 |EMTDP-06 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-8 |EMTDP-07 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AFLATOXIN EXTRACT AA 34-9 |EMTDP-08 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AGAR |9002-18-0 |TR-230, FEED, MR=N | | | | | | | FR=N, MM=N, FM=N | | | | | | | NTIS # PB82-227588 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AGARITINE |2757-90-6 |TR-00E, WATER, RPT COMP| | | | | | | NTIS # JOURNAL ART | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| |*AGENT ORANGE MIXTURE (2,4-D; |AGNTORANGEMX| | | |ORST, COMPLETED, NTIS #| | 2,4,5-T, TCDD) | | | | |PB86-132750 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALACHLOR (PESTICIDES MIXTURE)|15972-60-8 | | | |IMM, COMPLETED | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALDICARB (SEE ALSO ALDECARB |116-06-3 |TR-136, FEED, MR=N | |SA, - | | | OXIME (CAS 1646-75-9)) | | FR=N, MM=N, FM=N | |SA-N, - | | | | | NTIS # PB298511 | |ML, +,+ | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALDICARB OXIME (SEE ALSO |1646-75-9 | | |SA, - |IMM, - | | ALDICARB ( CAS 116-06-3 )) | | | |CY, -/-,-/- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALDRIN |309-00-2 |TR-021, FEED, MR=E | |SA, - | | | | | FR=E, MM=P, FM=N | | | | | | | NTIS # PB275666 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALIZARIN YELLOW R SODIUM SALT|1718-34-9 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| * See Special Mixtures at end of report for individual chemicals DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 12 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLOXAN MONOHYDRATE (SEE |3237-50-1 | | |SA, - | | | ALSO: ALLOXAN (CAS RN 50-71- | | | |DL, +/- | | | 5)) | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLURA RED C.I.16035 |25956-17-6 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ACETATE (ALLYL ALCOHOL |591-87-7 |TOX-48, GAV, SUBCH TOX |METABOLISM (IN- |SA, +,+ | | | (107-18-6)) | | |VITRO), ON TEST |MN, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ACRYLATE |999-55-3 | | |SA, -,- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ALCOHOL (ALLYL ACETATE |107-18-6 |TOX-48, GAV, SUBCH TOX | |SA, -,- | | | (591-87-7)) | | | |MN, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYLAMINE |107-11-9 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ANTHRANILATE |7493-63-2 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL BROMIDE |106-95-6 |GAV, ON TEST SUBCHRONIC|TKS (IN-VITRO), |SA, + | | | | |SP, COMPLETED RPD DOSE |REPORT | | | | | |GAV, ON TEST SUBCHRONIC| | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL CHLORIDE |107-05-1 |TR-073, GAV, MR=N | |SA, + | | | | | FR=N, MM=E, FM=E | | | | | | | NTIS # PB287516 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL GLYCIDYL ETHER |106-92-3 |TR-376, INHAL, MR=EE | |SA, + | | | | | FR=NE, MM=SE, FM=EE | |DL, +/- | | | | | NTIS # PB90-260027 | |CY, +/+ | | | | | | |MN, -/-,+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ISOTHIOCYANATE |57-06-7 |TR-234, GAV, MR=P |CHEM DISP (IV), |SA, -,+W | | | | | FR=E, MM=N, FM=N |PUBLICATION; |ML, + | | | | | NTIS # PB83-144238 |METABOLISM (GAV), |DL, -,- | | | | | |PUBLICATION |CY, +/+ | | | | | | |MN, -,-,- | | | | | | |CA, -,E | | | | | | |SC, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL ISOVALERATE |2835-39-4 |TR-253, GAV, MR=P | |SA, - | | | | | FR=N, MM=N, FM=P | |ML, + | | | | | NTIS # PB83-218214 | |DL, - | | | | | | |CY, +/+ | | | | | | |CA, - | | | | | | |SC, +* | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL NONANOATE |7493-72-3 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL PROPYL DISULFIDE |2179-59-1 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 13 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL THIOUREA |109-57-9 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALLYL UREA |557-11-9 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALUMINUM (SEE ALSO ALUMINUM |7429-90-5 | | | | | | OXIDE 1344-28-1) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ALUMINUM TRICHLORIDE |7446-70-0 | | | |RACB, DEFERRED | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMILORIDE (SEE ALSO: |2609-46-3 | | | | | | AMILORIDE HCL (2016-88-8)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMILORIDE HYDROCHLORIDE |2016-88-8 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOACETANILIDE (SEE ALSO |555-48-6 | | | | | | M & P-AMINOACETANILIDE) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOACETANILIDE |4801-39-2 | | |SA, + | | | HYDROCHLORIDE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | M-AMINOACETANILIDE |102-28-3 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-AMINO ACETANILIDE |122-80-5 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 9-AMINOACRIDINE (SEE ALSO 9- |90-45-9 | | |SA-N, + | | | AMINOACRIDINE HCL AND 9- | | | | | | | AMINOACRIDINE HCL-H2O) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 9-AMINOACRIDINE HYDROCHLORIDE|134-50-9 |SP, COMPLETED PRECHRONI|CHEM DISP (GAV, IV, | |RACB, MALE:-;FEMALE:+, | | (SEE ALSO 9-AMINOACRIDINE HCL| |FEED, COMPLETED PRECHRO|SP), REPORT & | |NTIS # PB86-163128 | | H2O 52417-22-8) | | |PUBLICATION | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 9-AMINOACRIDINE, |52417-22-8 | |TKS (GAV, IV), NO |SA, +,+,+ | | | MONOHYDROCHLORIDE, | | |REPORT IN FILE |DL, -,+/-,- | | | MONOHYDRATE (SEE ALSO 9- | | | |CY, +/+ | | | AMINOACRIDINE HYDROCHLORIDE | | | | | | | 134-50-9) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOANTHRACENE |613-13-8 | | |SA, +,+,+,+,+,+| | | | | | |SA-N, + | | | | | | |DL, +/+ | | | | | | |CY, ?/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOANTHRAQUINONE |117-79-3 |TR-144, FEED, MR=P | |SA, + | | | | | FR=IS, MM=P, FM=P | |SA-N, + | | | | | NTIS # PB287739 | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-AMINOAZOBENZENE |60-09-3 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | O-AMINOAZOTOLUENE |97-56-3 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 14 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINOBENZENESULFONIC ACID |121-47-1 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 4-AMINOBENZENESULFONIC ACID |121-57-3 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOBENZIMIDAZOLE |934-32-7 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-AMINOBENZOIC ACID |150-13-0 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOBENZOTHIAZOLE |136-95-8 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-CHLOROBENZOTHIAZOLE|19952-47-7 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-CHLORO-5- |6358-07-2 | | |SA, + | | | NITROPHENOL | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-6-CHLORO-4- |62625-14-3 | | |SA, + | | | NITROPHENOL HYDROCHLORIDE | | | | | | | (SEE ALSO CAS 6358-09-4) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-CHLOROPHENOL |95-85-2 | | |SA, +W | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 6-AMINO-4-CHLORO-1-PHENOL-2- |88-23-3 | | |SA, - | | | SULFONIC ACID | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 1-AMINOCYCLOPENTANE |52-52-8 | | |SA, - | | | CARBOXYLIC ACID | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 1-AMINO-2,4- |81-49-2 |TR-383, FEED, MR=CE |CHEM DISP (GAV, IV), |SA, + | | | DIBROMOANTHRAQUINONE | | FR=CE, MM=CE, FM=CE |REPORT |CY, ?/+,+W/+ | | | | | NTIS # PB97-116636 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-5,6- |29927-08-0 | | |SA, + | | | DIMETHYLBENZOTHIAZOLE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4,6-DINITROPHENOL |96-91-3 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINO-4-ETHOXYACETANILIDE |17026-81-2 |TR-112, FEED, MR=N | |SA, + | | | | | FR=N, MM=P, FM=N | |SA-N, + | | | | | NTIS # PB285194 | |DL, - | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-6-ETHOXYBENZOTHIAZOLE|94-45-1 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINO-9-ETHYLCARBAZOLE (SEE|132-32-1 | | | | | | ALSO THE HCL OF THIS CHEMICAL| | | | | | | - 6109-97-3) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINO-9-ETHYLCARBAZOLE HCL |6109-97-3 |TR-093, FEED, MR=P | |SA, + | | | | | FR=P, MM=P, FM=P | |CY, -/+ | | | | | NTIS # PB287126 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 15 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 4-AMINO-4'-HYDROXY-3-METHYL- |6219-89-2 | | |SA, + | | | DIPHENYLAMINE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4- |5464-79-9 | | |SA, + | | | METHOXYBENZOTHIAZOLE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 1-AMINO-2-METHYLANTHRAQUINONE|82-28-0 |TR-111, FEED, MR=P | |SA, + | | | | | FR=P, MM=N, FM=P | |CY, +/+ | | | | | NTIS # PB286852 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-METHYLBENZOTHIAZOLE|1477-42-5 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-METHYLPHENOL |95-84-1 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINO-6-METHYLPHENOL |2835-95-2 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-(METHYLSULFONYL) |98-30-6 | | |SA, - | | | PHENOL | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-6-NITROBENZOTHIAZOLE |6285-57-0 | | |SA, +,+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-NITROPHENOL |99-57-0 |TR-339, GAV, MR=SE | |SA, +,+ | | | | | FR=NE, MM=NE, FM=NE | |ML, + | | | | | NTIS # PB89-128623 | |CY, +/+ | | | | | | |MN, -,- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-5-NITROPHENOL |121-88-0 |TR-334, GAV, MR=SE | |SA, + | | | | | FR=NE, MM=NE, FM=NE | |ML, + | | | | | NTIS # PB88-184809 | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 4-AMINO-2-NITROPHENOL |119-34-6 |TR-094, FEED, MR=P | |SA, + | | | | | FR=E, MM=N, FM=N | |SA-N, + | | | | | NTIS # PB286189 | |ML, +,+ | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 6-AMINO-4-NITRO-1-PHENOL-2- |96-67-3 | | |SA, - | | | SULFONIC ACID | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-5-NITROTHIAZOLE |121-66-4 |TR-053, FEED, MR=P | |SA, + | | | | | FR=N, MM=N, FM=N | |SA-N, + | | | | | NTIS # PB283346 | |ML, +,+ | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINOPHENOL |591-27-5 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | O-AMINOPHENOL |95-55-6 | | |SA, +,+W,+ | | | | | | |DL, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-AMINOPHENOL |123-30-8 | | |SA, -,-,- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 16 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-1-PHENOL-4-SULFONIC |98-37-3 | | |SA, - | | | ACID | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-(4-AMINOPHENYL)-6-METHYL-7-|130-17-6 |FEED, COMPLETED PRECHRO| |SA, + | | | BENZOTHIAZOLE SULFONIC ACID | | | |MN, -/- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-PHENYLTHIAZOLE HBR |52253-69-7 | | |SA, + | | | H2O | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINOPYRIDINE |504-29-0 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 5-AMINOSALICYLIC ACID |89-57-6 | | |SA, - | | | | | | |CY, -/- | | | | | | |MN, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 5-AMINO-3-SULFOSALICYLIC ACID|6201-87-2 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-THIAZOLEACETIC ACID|29676-71-9 | | |SA, ?,? | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-THIAZOLINE HCL |3882-98-2 | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 2-AMINO-4-THIAZOLINE-4- |2150-55-2 | | |SA, - | | | CARBOXYLIC ACID | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINOTRIAZOLE |61-82-5 | | |SA, - | | | | | | |SA-N, - | | | | | | |ML, -,-,- | | | | | | |DL, -,? | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 3-AMINO-A,A,A- |98-16-8 | | |SA, - | | | TRIFLUOROTOLUENE | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | 11-AMINOUNDECANOIC ACID |2432-99-7 |TR-216, FEED, MR=P | |SA, - | | | | | FR=N, MM=E, FM=N | |ML, - | | | | | NTIS # PB82-225640 | |DL, - | | | | | | |CY, -/+ | | | | | | |MN, - | | | | | | |CA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMMONIUM LIGNINSULFONATE |8061-53-8 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMMONIUM NITRATE |6484-52-2 | | | | | | (PESTICIDE/FERTILIZER | | | | | | | MIXTURE) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMPHETAMINE (SEE ALSO: D- |300-62-9 | | | | | | AMPHETAMINE (51-64-9) & | | | | | | | AMPHETAMINE SULFATE (60-13- | | | | | | | 9)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 17 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | DL-AMPHETAMINE SULFATE (SEE |60-13-9 |TR-387, FEED, MR=NE | |SA, ? | | | ALSO: D-AMPHETAMINE SULFATE | | FR=NE, MM=NE, FM=NE | |CY, -/- | | | (CAS 51-63-8)) | | NTIS # PB92-107978 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMPHOTERICIN B |1397-89-3 | | |SA, - | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMPICILLIN (SEE ALSO |69-53-4 | | | | | | AMPICILLIN TRIHYDRATE 7177- | | | | | | | 48-2) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMPICILLIN TRIHYDRATE (SEE |7177-48-2 |TR-318, GAV, MR=EE | |SA, - | | | ALSO AMPICILLIN 69-53-4) | | FR=NE, MM=NE, FM=NE | |ML, - | | | | | NTIS # PB87-204160 | |CY, -/- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMSACRINE |51264-14-3 | | | |TRC, POSITIVE 1 | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMSCO SOLVENT F (SEE ALSO |EMTDP-69 | | |SA, -,- | | | BETA-BROMO-BETA-NITROSTYRENE)| | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| |*AMSCO SOLVENT F (65%) (AMSCO |AMSCO65SOLF | | |SA, + | | | SOLVENT F (100%)) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | N-AMYLAMINE |110-58-7 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AMYL NITRITE |463-04-7 | | |SA, +W,+W,+,+,+| | | | | | |SA, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANDROSTENEDIONE |63-05-8 |GAV, ASSIGNED |CHEM DISP (GAV, IN- | | | | | |SP, ASSIGNED RPD DOSE |VITRO), ON TEST | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANETHOLE |104-46-1 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANILAZINE |101-05-3 |TR-104, FEED, MR=N | |SA, - | | | | | FR=N, MM=N, FM=N | |SA-N, - | | | | | NTIS # PB287141 | |ML, +,+ | | | | | | |CY, -/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANILINE (SEE ALSO ANILINE |62-53-3 | | |SA, - | | | HYDROCHOLORIDE 142-04-1) | | | |ML, +,+,+,+ | | | | | | |DL, - | | | | | | |CY, +W/+ | | | | | | |MN, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANILINE HYDROCHLORIDE (SEE |142-04-1 |TR-130, FEED, MR=P | |SA-N, - | | | ALSO ANILINE 62-53-3) | | FR=P, MM=N, FM=N | | | | | | | NTIS # PB287539 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANISE OIL |8007-70-3 | | |SA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| * See Special Mixtures at end of report for individual chemicals DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 18 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | M-ANISIDINE |536-90-3 | | |SA, +W,+,- | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | O-ANISIDINE (SEE ALSO: O- |90-04-0 | | |SA, +,+,? | | | ANISIDINE HCL (134-29-2)) | | | |DL, - | | | | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | O-ANISIDINE HYDROCHLORIDE |134-29-2 |TR-089, FEED, MR=P | |SA-N, + | | | (SEE ALSO: O-ANISIDINE (90- | | FR=P, MM=P, FM=P | |MN, - | | | 04-0)) | | NTIS # PB285879 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-ANISIDINE (SEE ALSO: P- |104-94-9 | | |SA, +,+,- | | | ANISIDINE HCL (20265-97-8)) | | | |CY, +/+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | P-ANISIDINE HYDROCHLORIDE |20265-97-8 |TR-116, FEED, MR=E | |SA-N, + | | | (SEE ALSO TRANSGENIC MODEL | | FR=N, MM=N, FM=N | |ML, + | | | EVALUATION (P-ANISIDINE HCL))| | NTIS # PB286951 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANNATTO |1393-63-1 | | |SA, +,+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANTHRACENE |120-12-7 | | |SA, +W,+W | | | | | | |SA-N, - | | | | | | |ML, +,+ | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANTHRALIN |1143-38-0 | | |SA, - | | | | | | |CY, -/- | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | O-ANTHRANILIC ACID |118-92-3 |TR-036, FEED, MR=N | |SA, - | | | | | FR=N, MM=N, FM=N | |ML, +,+ | | | | | NTIS # PB278883 | |CY, +W/+ | | | | | | |CA, E | | | | | | |SC, + | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANTHRAQUINONE |84-65-1 |TR-494, FEED, MR=SE |CHEM DISP (GAV), |SA, + | | | | | FR=CE, MM=CE, FM=CE |REPORT; TKS (GAV, |MN, +,- | | | | | |IV), REPORT | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ANTIMONY POTASSIUM TARTRATE |28300-74-5 |TOX-11, IP/IJ, RPT COMP| |SA, - | | | | | NTIS # PB93-149714 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AROCHLOR 1260 (9CI) (CHEMICAL|11096-82-5 | | | | | | MIXTURE) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AROCLOR 1254 |11097-69-1 |TR-038, FEED, MR=E | |SA, - | | | | | FR=E | |SA-N, - | | | | | NTIS # PB279624 | |CY, -/-,-/+W | | | | | | |MN, NT,- | | | | | | |CA, - | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| DATE RUN: 08/10/00 RESULTS, STATUS AND PUBLICATION INFORMATION ON NTP CHEMICALS PAGE 19 |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | STUDY OR COMPOUND NAME | CAS NUMBER | CARCINOGENICITY/ |CHEMICAL DISPOSITION/| GENETIC | ORGAN SYSTEMS | | | | TOXICITY STUDIES | SPECIAL STUDIES | TOXICOLOGY | TOXICITY | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | AROTINOID (SEE RETINOID |125533-88-2 | | | | | | PROJECT 3) | | | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| |*ARSENIC TRIOXIDE |1327-53-3 | | | |NTA, COMPLETED | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ARSINE |7784-42-1 |INHAL, COMPLETED PRECHR|CHEM DISP (INHAL), | |TER, MAT:-;FET:- | | | | |PUBLICATION | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ASBESTOS, AMOSITE |12172-73-5 |TR-279, FEED, MR=N | | | | | | | FR=N | | | | | | | NTIS # PB91-172312 | | | | | | |TR-249, FEED, RPT COMPL| | | | | | | NTIS # PB87-133278 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ASBESTOS, AMOSITE + DIMETHYL |12172-73-5 |TR-279, FEED, MR=IS | | | | | HYDRAZINE (SEE ALSO ASBESTOS,| | FR=IS | | | | | AMOSITE) | | NTIS # PB91-172312 | | | | |------------------------------|------------|-----------------------|---------------------|---------------|-----------------------| | ASBESTOS, CHRYSOTILE(IR) |12001-29-5 |TR-295, FEED, MR=SE | | | | | | | FR=NE | | | | | | | NTIS # PB86-167103 | | | | | | |TR-246, FEED, RPT COMPL| | | | | | | NTIS # PB91-142380 | | | | | | |TR-295, FEED, RPT COMPL| | | | | | | NTIS # PB86-167103 | | | | |------------------------------|------------|-----------------------|---------------------|-----------